A suspected Palestinian gunman has killed an Israeli woman and seriously wounded a man in the south of the occupied West Bank, Israeli authorities said, as violence continued to flare in the territory shortly after another shooting killed two Israelis.

The latest attack is part of a sharp escalation in the region in recent months involving Palestinian militants, Israeli security forces and radical Jewish settlers.

It took place as Israeli forces were already on high alert and searching for the gunman who had killed the two Israelis in the northern West Bank on Saturday.

The combustible mix of armed Palestinians carrying out shooting attacks against Israelis as well as near-nightly – and often deadly – raids by the Israeli army to arrest militants has fuelled the worst fighting between Israel and the Palestinians in the West Bank in nearly two decades.

An Israeli soldier guards the site of the shooting (AP)

Reprisals by fanatic Jewish settlers against Palestinians have also heightened tensions in the territory.

On Sunday, Israeli settlers threw stones and firebombs at a Palestinian home south of Nablus near the site of Saturday’s deadly attack, local officials reported, causing damage but no injuries.

Israeli security forces said the suspected Palestinian gunman opened fire at an Israeli car on Route 60, the main north-south road in the West Bank, near the major city of Hebron.

The army said the apparent drive-by shooting killed an Israeli woman and seriously wounded a man as the two were travelling.

The Israeli rescue service reported the two victims were in their 40s and that a six-year-old girl who was also in the car was unharmed. The man, it said, was found semi-conscious and taken to hospital.

Authorities say that a suspected Palestinian attacker opened fire (AP)

Images from the scene showed the victims’ shattered sedan riddled with bullet holes. The gunman fled, prompting Israeli security forces to embark on their second manhunt in three days. The military shut down all entrances to the Palestinian city of Hebron along with other towns to the south and east.

The Hamas militant group and Palestinian Islamic Jihad praised the attack as a response to Israel’s expanding settlement enterprise in the West Bank, but stopped short of claiming responsibility.

The deadly shooting came just days after another Palestinian attack killed an Israeli father and son who were washing their car in the northern Palestinian town of Hawara, putting the West Bank on edge.

Nearly 180 Palestinians have been killed by Israeli fire in the West Bank since the start of this year, according to a tally by The Associated Press.

Israel says most of the Palestinians killed were militants, but stone-throwing youths protesting against the incursions and those not involved in the confrontations have also been killed.

Some 30 people have been killed by Palestinian attacks against Israelis during that time.

Israel says the raids are meant to dismantle militant networks and thwart future attacks. Palestinians say the raids undermine their security forces, inspire more militancy and entrench Israeli control over lands they seek for a hoped-for future state.